New-Year-2012-2013.jpg' alt='Cytomel Thyroid Weight Loss' title='Cytomel Thyroid Weight Loss' />Liothyronine Wikipedia. This article is about liothyronine as a pharmaceutical drug. For its role as a hormone, see Triiodothyronine. Liothyronine sodium. Clinical data. Trade names. Cytomel. AHFSDrugs. Consumer ratings reports for CYTOMEL. Includes 253 patient rankings on scale of 15, comments, side effects, dosage, sex, age, time taken. Page 1 of 5. The goal of thyroid hormone treatment is to closely replicate normal thyroid functioning. Pure, synthetic thyroxine T4 works in the same way as a patients own. More than 12 million Americans have thyroid disease. If youve be diagnosed with thyroid disease, you might be wondering if there is anything you can. Warning Do not use Cytomel liothyronine tablets to treat obesity or for weight loss. Very bad and sometimes deadly side effects may happen with this medicine if. Monograph. Medline. Plusa. 68. 24. 62. Pregnancycategory. US A No risk in human studiesATC code. Kf7-Zs5LkkzNsU87oGyFUoryEM=/735x0/whitepills3-56a9551b3df78cf772a5f26a.jpg' alt='Cytomel Thyroid Weight Loss' title='Cytomel Thyroid Weight Loss' />Legal status. Legal status. Pharmacokinetic data. Protein binding. 99. Biological half life. Identifierssodium S 2 amino 3 4 4 hydroxy 3 iodophenoxy 3,5 diiodophenylpropanoate. CAS Number. Pub. Chem. CIDIUPHARBPSDrug. Bank. Chem. Spider. UNIICh. EBICh. EMBLPDBligand. ECHA Info. Card. 10. World History Word Search Pdf. Adding-t3-to-NDT-for-weight-loss-and-energy.png' alt='Cytomel Thyroid Weight Loss' title='Cytomel Thyroid Weight Loss' />Chemical and physical data. Formula. C1. 5H1. I3. NNa. O4. Molar mass. D model JSmolNa. O COCHNCc. IcOc. 1ccIcOcc. Ic. OIn. Ch. I1. SC1. H1. 2I3. NO4. Na. H2. Oc. 16 9 6 81 2 1. H,5,1. 9H2,H,2. 1,2. H2q 1 p 1t. YKey IRGJMZGKFAPCCR LTCKWSDVSA M Y NY what is this  verifyLiothyronine is a synthetic form of triiodothyronine T3, a thyroid hormone used to treat hypothyroidism and myxedema coma. T3 is the metabolically active thyroid hormone, which causes feedback inhibition, and lowers elevated TSH levels. It increases metabolism in peripheral tissues and is indicated when there is an impaired conversion of T4 to T3 in peripheral tissues. It is also used as an augmentation strategy in treating major depressive disorder when used in combination with antidepressants. It is marketed as the sodium salt under the brand name Cytomel or Tertroxin in Australia. Physicians may use liothyronine instead of or in addition to levothyroxine T4 for patients undergoing thyroid hormone withdrawal. When a patient has thyroid cancer or Graves disease, ablation therapy with radioactive iodine 1. I can be used to remove trace thyroid tissue that may remain after thyroidectomy surgical excision of the gland. For 1. 31. I therapy to be effective, the trace thyroid tissue must be avid to iodine, which is achieved by elevating the patients TSH levels. For patients taking levothyroxine, TSH may be boosted by discontinuing levothyroxine for 36 weeks. This long period of hormone withdrawal is required because of levothyroxines relatively long biological half life, and may result in symptoms of hypothyroidism in the patient. The shorter half life of liothyronine permits a withdrawal period of two weeks, which may minimize hypothyroidism symptoms. One protocol is to discontinue levothyroxine, then prescribe liothyronine while the T4 levels are falling, and finally stop the liothyronine two weeks before the radioactive iodine treatment. Liothyronine may also be preferred for patients with myxedema coma because of its quicker onset of action when compared to levothyroxine. Low dose liothyronine has been shown to improve depression symptoms in patients with normal thyroid function who do not have adequate relief from their depression after trying several different antidepressants. When added to existing medications, liothyronine helped achieve remission in 2. STARD depression trial. According to a 2. Liothyronine to tricyclic antidepressants, women in particular may benefit from Liothyronine. The average effective dose for depression was 4. Liothyronine daily, which is lower than the doses used for treating hypothyroidism. About 9 of patients stopped taking liothyronine due to side effects. The difference in gender response may be due to differences in metabolism of thyroid precursors. An algorithm developed from the STAR trial recommends liothyronine as an option when patients have failed two antidepressant medications. Advantages in thyroid hormone replacementeditSee Hypothyroidism for an in depth explanation of hormone replacement. Liothyronine is an option for routine thyroid hormone replacement. It has a half life of 2. This compares to a half life of 7 days with levothyroxine. The shorter half life allows patients to know if they are taking too much indicated by a heart rate 1. It is recommended that labs be drawn monthly and the dose increased until the patients hypothyroid symptoms resolve. Per the liothyronine product insert, the starting dose may start at 5 mcg daily and increase by 5 mcg every two weeks. However, it should be noted that liothyronine should be taken with levothyroxine when liothyronine is taken long term to avoid potential heart rate and rhythm abnormalities. Taking both levothyhroxine and liothyronine separately allows for optimizing of reverse T3 and resolution of potential conversion problems of T4 to T3. Peripheral conversion problems are common when there is physiological stress this will be felt as increased fatigue. Sling 14 Day Trial Roku Stick there. Desiccated thyroid products have both T4 levothyroxine and T3 liothyronine in one tablet in a ratio of 4 to 1 T4 to T3. If the body does not metabolize thyroid hormones in this ratio which is possible due to a thyroid problem symptoms may worsen. This may be a reason to take levothyroxine and liothyronine separately and target for upper range for f. T3 and f. T4, with r. T3 in the bottom quartile. This is one therapeutic approach for patients who feel worse HR 1. These patients may benefit more from a customized ratio of T3T4 such as reducing the ratio from 4 1 to 3 1 to 2 1 and so on until both symptomatic improvement and labs in ideal range as explained above. Patients who still have complications after obtaining normal labs may benefit from a slow release formulation from a compounded pharmacy no slow release thyroid product is currently manufactured so it must be compounded. ContraindicationseditAny person with a hypersensitivity to liothyronine sodium or any active ingredient of the formulation should not be on this medication. If there is uncorrected adrenal insufficiency or thyrotoxicosis, a different approach to therapy must be considered. Liothyronine may cause a number of side effects, mostly similar to symptoms of hyperthyroidism, which include 1. Boxed warningeditThe package insert for Cytomel contains the following boxed warning, as do all thyroid hormones 1. Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Pregnancy Per the U. S. FDA, liothyronine is categorized as Pregnancy Category A. Thyroid hormone is minimally transferred to the fetus or placenta, however as of October 2. Hypothyroid mothers should continue to take thyroid hormone replacement therapy throughout pregnancy to avoid adverse events. Nursing Breastmilk contains a low amount of thyroid hormone, so it is important to exercise caution when breastfeeding while taking liothyronine. Elderly Elderly patients should be started on lower doses of liothyronine. Plasma T3 concentrations in this population are decreased by 2. TSH must be routinely monitored since there is a risk of coronary artery disease, hyperthyroidism and excessive bone loss from inadequate or abnormal thyroid replacement. PharmacologyeditLiothyronine is the most potent form of thyroid hormone. As a salt of triiodothyronine T3, it is chemically similar and pharmacologically equivalent to T3.